ZNF492

Across TCGA patient cohorts, ZNF492 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF492-associated genes across cancer lineages are 4E-BP1, p70-S6K_pT389, and ER-alpha_pS118. Each is linked with ZNF492 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF492-to-partner and partner-to-ZNF492 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ZNF492-low versus ZNF492-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF492→partner) and Y-score (partner→ZNF492) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.362	+2.837	<.001	.001	3	4
STAD	p70-S6K_pT389 →	-0.204	-3.169	.026	.018	3	3
LUSC	ER-alpha_pS118 →	+0.099	+3.505	.026	.002	3	2
LUSC	FoxM1 →	+0.286	+3.468	.026	.002	3	2
LUSC	MEK1_p_S217_S221 →	-0.147	-2.312	.030	.035	3	2
STAD	C-Raf →	+0.145	+2.321	.045	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

4E-BP1 by ZNF492 expression — UCEC

Explore this box plot interactively →