ZNF492

Across TCGA cell cohorts, ZNF492 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ZNF492-associated genes across cancer lineages are FCN2, TEX43, and GSG1L2. Each is linked with ZNF492 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF492-to-partner and partner-to-ZNF492 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCN2 grouped by ZNF492-low versus ZNF492-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF492→partner) and Y-score (partner→ZNF492) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FCN2 →	+0.039	+4.415	<.001	.007	3	1
LARGE_INTESTINE	TEX43 →	+0.152	+4.273	<.001	.006	3	1
LARGE_INTESTINE	GSG1L2 →	+0.020	+5.022	<.001	.002	3	1
LUNG_SCLC	BANF2 →	+0.311	+3.647	<.001	<.001	3	1
LUNG_SCLC	RTL4 →	+0.441	+3.866	.001	.002	3	1
LUNG_SCLC	OR10G4 →	+0.061	+3.099	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

FCN2 by ZNF492 expression — LARGE_INTESTINE

Explore this box plot interactively →