ZNF491

Across TCGA pan-cancer cohorts, ZNF491 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF491 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZNF491 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated ZNF491 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LUAD, and LUSC are the cancer types where ZNF491 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	1.000	0.312	.001	34	view →
LUAD	OS	Median	All	0.147	0.788	<.001	30	view →
LUSC	OS	Median	II,III,IV	0.181	0.742	.007	12	view →
SKCM	OS	Median	All	0.193	0.781	.003	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZNF491–UCEC (OS)

Open the UCEC breakdown →