ZNF491

Across TCGA patient cohorts, ZNF491 mutation is significantly associated with the RNA expression of many other genes, with 2,474 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF491-associated genes across cancer lineages are SNRPGP7, PRAMEF13, and RNU6-645P. Each is linked with ZNF491 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF491-to-partner and partner-to-ZNF491 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPGP7 grouped by ZNF491-low versus ZNF491-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF491→partner) and Y-score (partner→ZNF491) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SNRPGP7 →	+0.269	+3.380	<.001	.005	3	3
HNSC	PRAMEF13 →	+0.049	+5.772	<.001	.001	3	3
LUSC	RNU6-645P →	+0.376	+3.781	<.001	.007	3	3
UCEC	RTCB →	+0.471	+4.141	<.001	<.001	3	3
UCEC	PIMREG →	+0.806	+2.191	<.001	<.001	3	3
BLCA	RNU7-9P →	+0.512	+7.640	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,474 associations by consensus.

SNRPGP7 by ZNF491 expression — COAD

Explore this box plot interactively →