ZNF491

Across TCGA patient cohorts, ZNF491 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF491-associated genes across cancer lineages are MEK1, PKC-delta_pS664, and ATM. Each is linked with ZNF491 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF491-to-partner and partner-to-ZNF491 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ZNF491-low versus ZNF491-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF491→partner) and Y-score (partner→ZNF491) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.411	+2.000	<.001	<.001	3	2
UCEC	PKC-delta_pS664 →	-0.092	-1.797	.017	.025	3	2
UCEC	ATM →	-0.592	-2.000	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.400	+1.827	.038	.015	3	2
UCEC	c-Met_pY1235 →	+0.049	+1.290	.039	.034	3	2
UCEC	4E-BP1 →	+0.388	+3.906	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

MEK1 by ZNF491 expression — UCEC

Explore this box plot interactively →