Across TCGA patient cohorts, ZNF490 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF490-associated genes across cancer lineages are S6_pS240_S244, S6_pS235_S236, and SCD. Each is linked with ZNF490 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF490-to-partner and partner-to-ZNF490 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF490→partner) and Y-score (partner→ZNF490) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	S6_pS240_S244 →	+0.500	+2.321	.016	.035	3	2
SKCM	S6_pS235_S236 →	+0.458	+2.820	.030	.035	3	1
SKCM	SCD →	+0.179	+2.321	.014	.035	3	1
SKCM	Tuberin_pT1462 →	+0.321	+2.321	.022	.035	3	1
SKCM	Bak →	-0.253	-2.321	.021	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.132	-2.321	.033	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

ZNF490 survival (RNA) · tumor vs normal (RNA) · all ZNF490 data types