Across TCGA cell cohorts, ZNF490 mutation is significantly associated with the mutation status of many other genes, with 5,393 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF490-associated genes across cancer lineages are FES, ROBO2, and THNSL1. Each is linked with ZNF490 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF490-to-partner and partner-to-ZNF490 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF490→partner) and Y-score (partner→ZNF490) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FES →	+4.044	+5.000	.008	.008	1	3
CNS	ROBO2 →	+4.044	+5.000	.008	.008	1	3
CNS	THNSL1 →	+5.044	+5.614	.003	.003	1	3
CNS	PCDHGB6 →	+6.044	+6.044	.001	.001	1	3
BLOOD_Leukemia	UBA6 →	+5.321	+5.894	.002	.002	1	3
LARGE_INTESTINE	TG →	+1.462	+2.823	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,393 associations by consensus.

Exploration

ZNF490 survival (RNA) · tumor vs normal (RNA) · all ZNF490 data types