ZNF488

Across TCGA pan-cancer cohorts, ZNF488 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF488 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZNF488 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF488 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

UCEC, SARC, and ACC are the cancer types where ZNF488 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.361	0.781	<.001	12	view →
SARC	DFS	Median	All	0.023	0.596	<.001	6	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
LIHC	DFS	Median	II,III,IV	0.104	0.429	.028	3	view →
SKCM	DFS	Median	II,III,IV	0.858	0.676	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZNF488–UCEC (OS)

Open the UCEC breakdown →