ZNF488

Across TCGA patient cohorts, ZNF488 mutation is significantly associated with the RNA expression of many other genes, with 4,573 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF488-associated genes across cancer lineages are ADNP2, PGK1, and GSR. Each is linked with ZNF488 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF488-to-partner and partner-to-ZNF488 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADNP2 grouped by ZNF488-low versus ZNF488-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF488→partner) and Y-score (partner→ZNF488) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ADNP2 →	+0.490	+2.177	<.001	<.001	3	3
UCEC	PGK1 →	+0.626	+2.099	.001	<.001	3	3
UCEC	GSR →	+0.447	+2.008	.007	.001	3	3
UCEC	XPNPEP1 →	+0.438	+1.857	<.001	<.001	3	3
UCEC	SDHB →	+0.395	+1.857	<.001	<.001	3	3
UCEC	PSMC3IP →	+0.532	+2.684	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,573 associations by consensus.

ADNP2 by ZNF488 expression — UCEC

Explore this box plot interactively →