ZNF488

Across TCGA patient cohorts, ZNF488 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF488-associated genes across cancer lineages are ATM, Cyclin-B1, and EGFR_pY1068. Each is linked with ZNF488 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF488-to-partner and partner-to-ZNF488 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZNF488-low versus ZNF488-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF488→partner) and Y-score (partner→ZNF488) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.345	-1.794	.017	.024	3	3
SKCM	Cyclin-B1 →	+0.490	+1.597	.001	.040	3	3
COAD	EGFR_pY1068 →	-0.462	-3.157	.001	.018	3	2
UCEC	A-Raf_pS299 →	-0.112	-2.502	.003	.001	3	2
UCEC	JNK_pT183_Y185 →	-0.113	-1.415	.035	.043	3	2
UCEC	MEK1 →	+0.271	+1.847	.020	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ATM by ZNF488 expression — UCEC

Explore this box plot interactively →