ZNF488

Across TCGA cell cohorts, ZNF488 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF488-associated genes across cancer lineages are KRTAP10-2, ADGRG4, and UCP1. Each is linked with ZNF488 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF488-to-partner and partner-to-ZNF488 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-2 grouped by ZNF488-low versus ZNF488-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF488→partner) and Y-score (partner→ZNF488) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KRTAP10-2 →	+0.048	+3.257	<.001	.001	3	1
LUNG_NSCLC_LUAD	ADGRG4 →	+0.018	+4.212	<.001	.007	3	1
BLOOD_Leukemia	UCP1 →	+0.174	+3.999	.005	.005	3	1
BLOOD_Leukemia	GZMK →	+0.412	+4.037	.008	.004	3	1
BLOOD_Leukemia	HHLA1 →	+0.009	+3.551	<.001	.009	3	1
BLOOD_Leukemia	CRYAA →	+0.046	+3.705	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

KRTAP10-2 by ZNF488 expression — LARGE_INTESTINE

Explore this box plot interactively →