ZNF486

Across TCGA patient cohorts, ZNF486 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF486-associated genes across cancer lineages are ACC1, 4E-BP1_pT70, and EGFR_pY1068. Each is linked with ZNF486 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF486-to-partner and partner-to-ZNF486 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by ZNF486-low versus ZNF486-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF486→partner) and Y-score (partner→ZNF486) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	ACC1 →	+0.414	+3.000	.043	.036	3	2
BLCA	4E-BP1_pT70 →	+0.211	+2.845	.009	.033	3	1
UCEC	EGFR_pY1068 →	-0.221	-1.807	.033	.027	3	1
UCEC	p62 Lck ligand →	+0.445	+2.321	<.001	.006	3	1
UCEC	PDCD4 →	-0.548	-2.999	.004	.035	3	1
UCEC	STAT3_pY705 →	-0.385	-3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ACC1 by ZNF486 expression — BLCA

Explore this box plot interactively →