ZNF486

Across TCGA cell cohorts, ZNF486 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF486-associated genes across cancer lineages are MAGEB4, OBP2A, and LYZL4. Each is linked with ZNF486 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF486-to-partner and partner-to-ZNF486 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by ZNF486-low versus ZNF486-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF486→partner) and Y-score (partner→ZNF486) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	1
LARGE_INTESTINE	OBP2A →	+0.094	+2.556	<.001	.006	3	1
LARGE_INTESTINE	LYZL4 →	+0.171	+2.819	<.001	.006	3	1
LARGE_INTESTINE	IL20 →	+0.202	+3.470	<.001	<.001	3	1
LARGE_INTESTINE	OR10W1 →	+0.008	+2.977	<.001	.006	3	1
LARGE_INTESTINE	KRTAP10-6 →	+0.032	+2.669	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

MAGEB4 by ZNF486 expression — LARGE_INTESTINE

Explore this box plot interactively →