Across TCGA patient cohorts, ZNF485 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF485-associated genes across cancer lineages are EGFR_pY1068, FASN, and Cyclin-E2. Each is linked with ZNF485 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF485-to-partner and partner-to-ZNF485 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF485→partner) and Y-score (partner→ZNF485) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.252	-2.115	.006	.016	3	2
UCEC	FASN →	+0.317	+1.502	.028	.030	3	2
UCEC	Cyclin-E2 →	+0.140	+1.710	.023	.025	3	2
UCEC	FoxM1 →	+0.260	+2.736	.006	<.001	3	1
UCEC	ACC1 →	+0.327	+1.750	.014	.049	3	1
UCEC	JNK_pT183_Y185 →	-0.155	-2.115	.012	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

ZNF485 survival (RNA) · tumor vs normal (RNA) · all ZNF485 data types