ZNF484

Across TCGA patient cohorts, ZNF484 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF484-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and JNK2. Each is linked with ZNF484 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF484-to-partner and partner-to-ZNF484 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZNF484-low versus ZNF484-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF484→partner) and Y-score (partner→ZNF484) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.520	+2.189	.007	.001	3	3
UCEC	eIF4E →	+0.141	+1.750	.041	.049	3	2
UCEC	JNK2 →	+0.213	+2.263	.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.367	+2.999	<.001	<.001	3	2
UCEC	PCNA →	+0.191	+1.938	.007	.001	3	2
UCEC	PDCD4 →	-0.561	-1.838	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Caspase-7-cleavedD198 by ZNF484 expression — UCEC

Explore this box plot interactively →