Across TCGA pan-cancer cohorts, ZNF480 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF480 data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher ZNF480 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF480 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SCLC, UCEC, and LUAD are the cancer types where ZNF480 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	All	0.055	0.708	<.001	36	view →
UCEC	DFS	Median	All	1.000	0.616	.003	36	view →
LUAD	OS	Median	III,IV	0.163	0.663	.012	24	view →
LIHC	DFS	Median	All	0.097	0.543	.033	6	view →
SKCM	OS	Median	IV	0.415	0.861	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: ZNF480 tumor-vs-normal RNA expression · all ZNF480 data types