Across TCGA patient cohorts, ZNF480 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF480-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and MEK1. Each is linked with ZNF480 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF480-to-partner and partner-to-ZNF480 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF480→partner) and Y-score (partner→ZNF480) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.590	+2.341	.005	.003	3	3
UCEC	14-3-3_beta →	-0.072	-1.847	.047	.049	3	2
UCEC	MEK1 →	+0.444	+3.087	<.001	<.001	3	2
UCEC	C-Raf →	+0.202	+1.925	<.001	.005	3	2
SKCM	Chk1 →	+0.267	+2.841	.021	.035	3	1
UCEC	FoxM1 →	+0.198	+1.584	.034	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration

ZNF480 survival (RNA) · tumor vs normal (RNA) · all ZNF480 data types