ZNF48

Across TCGA pan-cancer cohorts, ZNF48 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ZNF48 data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ZNF48 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF48 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

PDAC, HNSC, and UCEC are the cancer types where ZNF48 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.307	0.566	.003	28	view →
HNSC	DFS	Quartile	All	1.000	0.868	.004	21	view →
UCEC	DFS	Median	All	0.850	0.967	.013	8	view →
CCRCC	DFS	Tertile	III,IV	0.505	0.886	.009	8	view →
LUAD	DFS	Quartile	All	0.840	0.957	.006	8	view →
LSCC	DFS	Tertile	All	0.959	0.898	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ZNF48–PDAC (DFS)

Open the PDAC breakdown →