ZNF474

Across TCGA pan-cancer cohorts, ZNF474 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated ZNF474 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF474 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF474 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, COAD, and DLBC are the cancer types where ZNF474 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.069	0.768	<.001	24	view →
COAD	DFS	Median	All	0.164	0.783	<.001	15	view →
DLBC	OS	Median	All	0.053	0.936	<.001	12	view →
OV	DFS	Median	All	0.142	0.541	.002	12	view →
STAD	OS	Median	IV	0.001	0.544	<.001	12	view →
KIRC	OS	Median	All	0.181	0.655	.046	6	view →
LUAD	OS	Median	II,III,IV	0.235	0.709	.030	6	view →
UCEC	DFS	Median	All	1.000	0.635	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

ZNF474–HNSC (OS)

Open the HNSC breakdown →