ZNF474

Across TCGA patient cohorts, ZNF474 protein abundance is significantly associated with the RNA expression of many other genes, with 1,246 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ZNF474-associated genes across cancer lineages are PPP1R32, EFHB, and AKAP14. Each is linked with ZNF474 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF474-to-partner and partner-to-ZNF474 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZNF474 versus PPP1R32 in LSCC, with a Pearson correlation of 0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF474→partner) and Y-score (partner→ZNF474) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PPP1R32 →	+0.879	+1.197	.003	.004	3	2
LSCC	EFHB →	+1.458	+1.558	.008	<.001	3	2
LUAD	AKAP14 →	+2.050	+1.114	.006	.005	3	2
LSCC	ME1 →	-1.878	-1.369	.001	.002	3	2
LUAD	PXMP4 →	-0.947	-0.782	.006	.005	3	1
LUAD	FAM83D →	-2.369	-0.782	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,246 associations by consensus.

ZNF474 vs PPP1R32 — LSCC

Explore this scatter interactively →