ZNF474

Across TCGA patient cohorts, ZNF474 mutation is significantly associated with the RNA expression of many other genes, with 2,358 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF474-associated genes across cancer lineages are EIF2B3, FDX1P2, and RBPJP5. Each is linked with ZNF474 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF474-to-partner and partner-to-ZNF474 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF2B3 grouped by ZNF474-low versus ZNF474-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF474→partner) and Y-score (partner→ZNF474) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EIF2B3 →	+0.517	+3.871	<.001	<.001	3	3
READ	FDX1P2 →	+0.239	+5.925	<.001	.002	3	2
STAD	RBPJP5 →	+0.023	+4.705	.003	.001	3	2
UCEC	ZNHIT3 →	+0.405	+2.523	.006	.001	3	2
UCEC	H2AC14 →	+1.214	+3.010	<.001	<.001	3	2
UCEC	H2AC16 →	+0.538	+2.010	.004	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,358 associations by consensus.

EIF2B3 by ZNF474 expression — UCEC

Explore this box plot interactively →