ZNF474

Across TCGA patient cohorts, ZNF474 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF474-associated genes across cancer lineages are ACC1, p62 Lck ligand, and C-Raf. Each is linked with ZNF474 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF474-to-partner and partner-to-ZNF474 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by ZNF474-low versus ZNF474-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF474→partner) and Y-score (partner→ZNF474) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.465	+3.013	.003	.018	3	2
UCEC	p62 Lck ligand →	+0.405	+2.999	.004	.035	3	2
UCEC	C-Raf →	+0.142	+2.115	.022	.019	3	2
SKCM	p38-MAPK_pT180_Y182 →	-0.350	-2.584	.029	.011	3	2
UCEC	eEF2 →	+0.364	+2.999	.019	.035	3	1
UCEC	EGFR_pY1068 →	-0.299	-3.321	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ACC1 by ZNF474 expression — UCEC

Explore this box plot interactively →