ZNF474

Across TCGA cell cohorts, ZNF474 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,838 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ZNF474-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, and Peptidyl-lysine oxidation. Each is linked with ZNF474 in more than 8 cancer types. Because this analysis shows association rather than direction, both ZNF474-to-partner and partner-to-ZNF474 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by ZNF474-low versus ZNF474-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF474→partner) and Y-score (partner→ZNF474) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of myoblast fusion →	+0.070	+0.130	<.001	.005	2	8
BONE	Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway →	+0.096	+0.363	.006	.005	1	9
BONE	Peptidyl-lysine oxidation →	+1.096	+0.431	.006	.007	3	6
LUNG_NSCLC_LUAD	Regulation of telomere maintenance via telomere lengthening →	+0.040	+0.241	<.001	.004	3	6
BLOOD_Leukemia	Spliceosomal complex assembly →	+0.079	+0.135	<.001	<.001	3	6
BLOOD_Leukemia	Regulation of mRNA splicing, via spliceosome →	+0.068	+0.098	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,838 associations by consensus.

Negative regulation of myoblast fusion by ZNF474 expression — PANCREAS

Explore this box plot interactively →