ZNF474

Across TCGA cell cohorts, ZNF474 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ZNF474-associated genes across cancer lineages are CSN2, OR5A1, and P2RY13. Each is linked with ZNF474 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF474-to-partner and partner-to-ZNF474 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSN2 grouped by ZNF474-low versus ZNF474-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF474→partner) and Y-score (partner→ZNF474) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CSN2 →	+0.078	+4.415	<.001	.007	3	1
SKIN	OR5A1 →	+0.015	+5.022	<.001	.002	3	1
SKIN	P2RY13 →	+0.006	+4.684	<.001	.002	3	1
BLOOD_Leukemia	H1-8 →	+0.011	+4.922	.007	.009	3	1
LARGE_INTESTINE	FAM71A →	+0.058	+3.453	.002	.009	3	1
LARGE_INTESTINE	RAX2 →	+0.073	+3.196	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

CSN2 by ZNF474 expression — SKIN

Explore this box plot interactively →