ZNF473

Across TCGA patient cohorts, ZNF473 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF473-associated genes across cancer lineages are Shc_pY317, FoxM1, and ACC1. Each is linked with ZNF473 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF473-to-partner and partner-to-ZNF473 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by ZNF473-low versus ZNF473-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF473→partner) and Y-score (partner→ZNF473) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.124	-2.115	.010	.016	3	3
STAD	FoxM1 →	+0.424	+3.321	<.001	.010	3	2
STAD	ACC1 →	+0.459	+2.190	.026	.033	3	2
UCEC	EGFR_pY1068 →	-0.211	-1.777	.008	.002	3	2
UCEC	A-Raf_pS299 →	-0.088	-1.584	.020	.034	3	2
UCEC	MEK1 →	+0.376	+2.321	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Shc_pY317 by ZNF473 expression — UCEC

Explore this box plot interactively →