ZNF473

Across TCGA cell cohorts, ZNF473 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF473-associated genes across cancer lineages are LRIT1, GUCA2A, and SLC32A1. Each is linked with ZNF473 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF473-to-partner and partner-to-ZNF473 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRIT1 grouped by ZNF473-low versus ZNF473-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF473→partner) and Y-score (partner→ZNF473) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LRIT1 →	+0.032	+4.269	<.001	.002	3	2
BLOOD_Leukemia	GUCA2A →	+0.031	+4.384	<.001	.006	3	2
BLOOD_Leukemia	SLC32A1 →	+0.537	+3.901	.002	.006	3	1
BLOOD_Leukemia	UNC93A →	+0.141	+3.944	<.001	.006	3	1
BLOOD_Leukemia	NPFFR1 →	+0.015	+4.037	<.001	.004	3	1
BLOOD_Leukemia	ODF1 →	+0.066	+3.944	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

LRIT1 by ZNF473 expression — BLOOD_Leukemia

Explore this box plot interactively →