Across TCGA pan-cancer cohorts, ZNF469 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF469 data layer compared with 20 for mass-spec protein.
The strongest signal is observed in esophageal carcinoma (ESCA), where higher ZNF469 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF469 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.
ESCA, BRCA, and KICH are the cancer types where ZNF469 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.