ZNF462

Across TCGA patient cohorts, ZNF462 mutation is significantly associated with the RNA expression of many other genes, with 9,008 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF462-associated genes across cancer lineages are CDKN3, ATP1B2, and FAXDC2. Each is linked with ZNF462 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZNF462-to-partner and partner-to-ZNF462 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDKN3 grouped by ZNF462-low versus ZNF462-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF462→partner) and Y-score (partner→ZNF462) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	CDKN3 →	+0.706	+2.584	<.001	.001	3	5
SKCM	ATP1B2 →	-1.127	-1.467	.004	.006	3	5
STAD	FAXDC2 →	-0.860	-3.794	<.001	<.001	3	5
STAD	CDCA4 →	+0.476	+2.475	.007	.009	3	5
UCEC	PGAM1 →	+0.692	+1.721	<.001	<.001	3	5
STAD	PRC1 →	+0.683	+2.601	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,008 associations by consensus.

CDKN3 by ZNF462 expression — STAD

Explore this box plot interactively →