ZNF462

Across TCGA patient cohorts, ZNF462 mutation is significantly associated with the total protein of many other genes, with 99 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF462-associated genes across cancer lineages are PCNA, eEF2, and eIF4E. Each is linked with ZNF462 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZNF462-to-partner and partner-to-ZNF462 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ZNF462-low versus ZNF462-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF462→partner) and Y-score (partner→ZNF462) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.282	+1.423	<.001	.028	3	5
COAD	eEF2 →	+0.310	+2.222	.001	.009	3	4
COAD	eIF4E →	+0.179	+2.128	.002	.009	3	4
COAD	GAPDH →	+0.639	+2.115	<.001	.015	3	4
STAD	Caveolin-1 →	-0.683	-2.321	.015	.032	3	4
UCEC	Cyclin-B1 →	+0.435	+1.777	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

PCNA by ZNF462 expression — COAD

Explore this box plot interactively →