ZNF462

Across TCGA cell cohorts, ZNF462 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,166 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ZNF462-associated GO terms across cancer lineages are Nucleus organization, Regulation of translational initiation, and Positive regulation of cytoplasmic translation. Each is linked with ZNF462 in more than 12 cancer types. Because this analysis shows association rather than direction, both ZNF462-to-partner and partner-to-ZNF462 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleus organization grouped by ZNF462-low versus ZNF462-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF462→partner) and Y-score (partner→ZNF462) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Nucleus organization →	+0.059	+0.944	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of translational initiation →	+0.080	+0.986	.004	.001	3	13
OVARY	Positive regulation of cytoplasmic translation →	+0.124	+1.085	.001	.004	3	13
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.119	+1.144	.001	<.001	3	13
LUNG_SCLC	Negative regulation of organelle assembly →	+0.069	+1.632	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.107	+0.908	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,166 associations by consensus.

Nucleus organization by ZNF462 expression — BREAST

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