Across TCGA patient cohorts, ZNF461 mutation is significantly associated with the RNA expression of many other genes, with 3,799 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF461-associated genes across cancer lineages are TRIM60P3Y, PPP1R26P4, and CDK4P1. Each is linked with ZNF461 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF461-to-partner and partner-to-ZNF461 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF461→partner) and Y-score (partner→ZNF461) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRIM60P3Y →	+0.025	+7.057	<.001	.009	3	3
BRCA	PPP1R26P4 →	+0.009	+4.341	<.001	.009	3	2
READ	CDK4P1 →	+0.161	+5.421	<.001	.005	3	2
READ	BPNT2P →	+0.148	+6.681	<.001	<.001	3	2
UCEC	IGHD3-9 →	+1.050	+1.798	<.001	<.001	3	2
UCEC	HINT1P1 →	+0.530	+3.353	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,799 associations by consensus.

Exploration

ZNF461 survival (RNA) · tumor vs normal (RNA) · all ZNF461 data types