Across TCGA patient cohorts, ZNF461 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF461-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and JNK_pT183_Y185. Each is linked with ZNF461 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF461-to-partner and partner-to-ZNF461 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF461→partner) and Y-score (partner→ZNF461) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.255	-2.874	.004	<.001	3	2
UCEC	eIF4E →	+0.183	+2.392	.014	<.001	3	1
UCEC	JNK_pT183_Y185 →	-0.153	-2.807	.010	.003	3	1
UCEC	MEK1 →	+0.282	+1.807	.029	.025	3	1
UCEC	NF-kB-p65_pS536 →	-0.382	-3.321	.017	.009	3	1
UCEC	Notch1 →	+0.147	+1.710	.003	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

ZNF461 survival (RNA) · tumor vs normal (RNA) · all ZNF461 data types