Across TCGA pan-cancer cohorts, ZNF460 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZNF460 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ZNF460 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF460 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where ZNF460 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	0.434	0.882	.001	72	view →
HNSC	DFS	Tertile	II,III,IV	0.974	0.869	.004	18	view →
LUAD	OS	Tertile	II,III,IV	0.767	0.320	.032	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: ZNF460 tumor-vs-normal RNA expression · all ZNF460 data types