Across TCGA patient cohorts, ZNF460 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF460-associated genes across cancer lineages are p62 Lck ligand, Annexin-1, and Src_pY527. Each is linked with ZNF460 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF460-to-partner and partner-to-ZNF460 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF460→partner) and Y-score (partner→ZNF460) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.356	+3.469	.008	.002	2	3
UCEC	Annexin-1 →	+0.487	+2.827	.025	.035	3	2
UCEC	Src_pY527 →	-0.435	-2.449	.014	.019	3	2
UCEC	Caspase-7-cleavedD198 →	+0.799	+2.604	.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.308	-3.000	.002	.001	3	1
UCEC	EGFR →	-0.181	-1.807	.006	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

ZNF460 survival (RNA) · tumor vs normal (RNA) · all ZNF460 data types