ZNF454

Across TCGA patient cohorts, ZNF454 mutation is significantly associated with the RNA expression of many other genes, with 3,925 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF454-associated genes across cancer lineages are ZSCAN22, CDCA2, and ARHGAP19. Each is linked with ZNF454 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF454-to-partner and partner-to-ZNF454 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZSCAN22 grouped by ZNF454-low versus ZNF454-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF454→partner) and Y-score (partner→ZNF454) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZSCAN22 →	+0.318	+2.700	.001	<.001	3	3
UCEC	CDCA2 →	+0.749	+2.321	<.001	<.001	3	3
UCEC	ARHGAP19 →	+0.519	+2.332	<.001	<.001	3	3
UCEC	MAPK1 →	+0.552	+4.032	<.001	<.001	3	3
UCEC	XPNPEP1 →	+0.498	+2.321	<.001	<.001	3	3
UCEC	NSD2 →	+0.446	+1.470	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,925 associations by consensus.

ZSCAN22 by ZNF454 expression — UCEC

Explore this box plot interactively →