ZNF454

Across TCGA patient cohorts, ZNF454 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF454-associated genes across cancer lineages are eIF4E, p27_pT198, and Rad50. Each is linked with ZNF454 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF454-to-partner and partner-to-ZNF454 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZNF454-low versus ZNF454-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF454→partner) and Y-score (partner→ZNF454) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.154	+1.847	.046	.008	3	3
UCEC	p27_pT198 →	+0.081	+2.736	.039	<.001	3	2
UCEC	Rad50 →	-0.182	-3.446	.040	.005	3	2
UCEC	TFRC →	+0.460	+3.169	.018	.018	3	2
UCEC	Bcl-2 →	-0.314	-2.095	.013	.017	3	2
UCEC	Caspase-7-cleavedD198 →	+0.471	+1.720	.030	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eIF4E by ZNF454 expression — UCEC

Explore this box plot interactively →