ZNF454

Across TCGA cell cohorts, ZNF454 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,470 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF454-associated GO terms across cancer lineages are Nucleic acid catabolic process, Nuclear export, and mRNA catabolic process. Each is linked with ZNF454 in more than 8 cancer types. Because this analysis shows association rather than direction, both ZNF454-to-partner and partner-to-ZNF454 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleic acid catabolic process grouped by ZNF454-low versus ZNF454-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF454→partner) and Y-score (partner→ZNF454) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Nucleic acid catabolic process →	+0.043	+0.579	<.001	<.001	3	9
CNS	Nuclear export →	+0.049	+0.361	<.001	.008	3	8
LUNG_SCLC	mRNA catabolic process →	+0.048	+0.769	<.001	<.001	3	8
LUNG_SCLC	RNA export from nucleus →	+0.084	+1.151	.003	<.001	3	8
CNS	RNA catabolic process →	+0.047	+0.576	<.001	<.001	3	8
BONE	Regulation of syncytium formation by plasma membrane fusion →	+0.077	+0.725	.004	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,470 associations by consensus.

Nucleic acid catabolic process by ZNF454 expression — CNS

Explore this box plot interactively →