ZNF454

Across TCGA cell cohorts, ZNF454 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ZNF454-associated genes across cancer lineages are KCNA10, LCE5A, and ZCCHC13. Each is linked with ZNF454 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF454-to-partner and partner-to-ZNF454 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNA10 grouped by ZNF454-low versus ZNF454-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF454→partner) and Y-score (partner→ZNF454) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KCNA10 →	+0.046	+3.977	<.001	.005	3	1
LUNG_NSCLC_LUAD	LCE5A →	+0.050	+3.770	.006	.008	3	1
LUNG_NSCLC_LUAD	ZCCHC13 →	+0.014	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	ETV3L →	+0.025	+4.093	.001	.004	3	1
LUNG_NSCLC_LUAD	KCNK16 →	+0.023	+4.189	<.001	.002	3	1
BLOOD_Leukemia	CNGA2 →	+0.099	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

KCNA10 by ZNF454 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →