ZNF451

Across TCGA pan-cancer cohorts, ZNF451 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated ZNF451 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ZNF451 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF451 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

LUAD, KIRC, and KIRP are the cancer types where ZNF451 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.269	0.669	<.001	42	view →
KIRC	OS	Median	All	0.250	0.812	.006	36	view →
KIRP	OS	Median	All	0.141	0.904	<.001	36	view →
UCEC	DFS	Median	All	0.952	0.600	<.001	34	view →
COAD	OS	Median	III,IV	0.204	0.798	<.001	24	view →
ESCA	OS	Median	III,IV	0.108	0.574	<.001	12	view →
LUSC	DFS	Median	All	1.000	0.633	.018	9	view →
SARC	DFS	Median	All	0.069	0.632	<.001	6	view →
SKCM	DFS	Median	II,III,IV	0.087	0.708	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

ZNF451–LUAD (DFS)

Open the LUAD breakdown →