ZNF451

Across TCGA pan-cancer cohorts, ZNF451 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF451 data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ZNF451 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF451 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

COAD, CCRCC, and LUAD are the cancer types where ZNF451 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	III,IV	1.000	0.731	.022	30	view →
CCRCC	OS	Median	All	0.613	0.985	.012	10	view →
LUAD	OS	Tertile	III,IV	0.844	0.388	.021	8	view →
HNSC	OS	Quartile	III,IV	0.821	0.960	.037	5	view →
LSCC	OS	Tertile	II,III,IV	1.000	0.886	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZNF451–COAD (DFS)

Open the COAD breakdown →