Across TCGA pan-cancer cohorts, ZNF451-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ZNF451-AS1’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZNF451-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF451-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.
HNSC, THCA, and LIHC are the cancer types where ZNF451-AS1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF451-AS1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.