ZNF45

Across TCGA patient cohorts, ZNF45 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF45-associated genes across cancer lineages are p62 Lck ligand, HSP70, and MEK1. Each is linked with ZNF45 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF45-to-partner and partner-to-ZNF45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ZNF45-low versus ZNF45-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF45→partner) and Y-score (partner→ZNF45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.330	+3.169	.020	.018	3	2
UCEC	HSP70 →	-0.411	-3.312	.019	.010	3	1
UCEC	MEK1 →	+0.344	+3.000	.031	.036	3	1
UCEC	Rab25 →	-0.489	-3.169	<.001	.018	3	1
UCEC	Annexin-1 →	+0.472	+3.019	.040	.019	3	1
UCEC	S6_pS240_S244 →	+0.489	+2.115	.005	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

p62 Lck ligand by ZNF45 expression — UCEC

Explore this box plot interactively →