ZNF45

Across TCGA cell cohorts, ZNF45 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF45-associated genes across cancer lineages are NEUROG3, CCR8, and ENPP7. Each is linked with ZNF45 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF45-to-partner and partner-to-ZNF45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEUROG3 grouped by ZNF45-low versus ZNF45-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF45→partner) and Y-score (partner→ZNF45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	NEUROG3 →	+0.006	+5.087	<.001	.004	3	2
SOFT_TISSUE	CCR8 →	+0.016	+4.369	<.001	.008	3	1
SOFT_TISSUE	ENPP7 →	+0.004	+4.369	<.001	.008	3	1
SOFT_TISSUE	GPX6 →	+0.017	+4.369	<.001	.008	3	1
SOFT_TISSUE	LRRC72 →	+0.271	+4.369	<.001	.008	3	1
BREAST	REG1B →	+1.039	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

NEUROG3 by ZNF45 expression — URINARY_TRACT

Explore this box plot interactively →