ZNF449

Across TCGA patient cohorts, ZNF449 protein abundance is significantly associated with the RNA expression of many other genes, with 296 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ZNF449-associated genes across cancer lineages are CD99L2, PHKB, and MEFV. Each is linked with ZNF449 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF449-to-partner and partner-to-ZNF449 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZNF449 versus CD99L2 in GBM, with a Pearson correlation of -0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF449→partner) and Y-score (partner→ZNF449) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CD99L2 →	-0.464	-0.621	<.001	<.001	3	1
GBM	PHKB →	-0.261	-0.345	.007	.001	3	1
GBM	MEFV →	+0.626	+0.440	.003	<.001	3	1
GBM	IDS →	-0.466	-0.357	.004	.002	3	1
GBM	CXCL12 →	+0.761	+0.308	<.001	.005	3	1
GBM	LHPP →	-0.581	-0.558	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 296 associations by consensus.

ZNF449 vs CD99L2 — GBM

Explore this scatter interactively →