ZNF449

Across TCGA patient cohorts, ZNF449 mutation is significantly associated with the RNA expression of many other genes, with 3,065 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF449-associated genes across cancer lineages are IER3IP1, ATG12P1, and MAPK6P6. Each is linked with ZNF449 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF449-to-partner and partner-to-ZNF449 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IER3IP1 grouped by ZNF449-low versus ZNF449-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF449→partner) and Y-score (partner→ZNF449) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IER3IP1 →	+0.367	+2.301	.001	<.001	3	3
UCEC	ATG12P1 →	+0.288	+1.452	<.001	.002	3	3
SKCM	MAPK6P6 →	+0.035	+2.958	.005	.005	3	3
UCEC	ADAM33 →	-0.741	-3.034	.001	<.001	3	2
UCEC	MTA2 →	+0.253	+1.515	.009	.006	3	2
UCEC	ATP5F1A →	+0.330	+1.595	.004	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,065 associations by consensus.

IER3IP1 by ZNF449 expression — UCEC

Explore this box plot interactively →