ZNF449

Across TCGA patient cohorts, ZNF449 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF449-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and Rad50. Each is linked with ZNF449 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF449-to-partner and partner-to-ZNF449 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZNF449-low versus ZNF449-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF449→partner) and Y-score (partner→ZNF449) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.179	+2.178	.001	.035	2	3
UCEC	MEK1 →	+0.348	+2.392	.001	<.001	3	2
UCEC	Rad50 →	-0.148	-1.473	.046	.006	3	2
COAD	Stathmin →	+0.142	+2.178	.048	.035	3	1
COAD	XBP1 →	+0.242	+2.178	.006	.035	3	1
COAD	c-Met_pY1235 →	+0.094	+3.000	.047	.035	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Caspase-7-cleavedD198 by ZNF449 expression — COAD

Explore this box plot interactively →