ZNF449

Across TCGA cell cohorts, ZNF449 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,865 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF449-associated GO terms across cancer lineages are Negative regulation of organelle assembly, Phosphatidylinositol biosynthetic process, and Cilium or flagellum-dependent cell motility. Each is linked with ZNF449 in more than 13 cancer types. Because this analysis shows association rather than direction, both ZNF449-to-partner and partner-to-ZNF449 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of organelle assembly grouped by ZNF449-low versus ZNF449-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF449→partner) and Y-score (partner→ZNF449) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of organelle assembly →	+0.091	+0.761	.001	<.001	3	14
PANCREAS	Phosphatidylinositol biosynthetic process →	+0.045	+0.467	.001	.007	3	14
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.117	-0.849	<.001	<.001	3	13
LARGE_INTESTINE	Regulation of organelle assembly →	+0.044	+0.612	<.001	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Flagellated sperm motility →	-0.122	-0.862	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Cilium-dependent cell motility →	-0.117	-0.849	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,865 associations by consensus.

Negative regulation of organelle assembly by ZNF449 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →