ZNF449

Across TCGA cell cohorts, ZNF449 mutation is significantly associated with the drug of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF449-associated genes across cancer lineages are AZD5153, CD532, and 123138. Each is linked with ZNF449 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF449-to-partner and partner-to-ZNF449 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AZD5153 grouped by ZNF449-low versus ZNF449-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF449→partner) and Y-score (partner→ZNF449) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AZD5153 →	+0.500	+2.649	.048	.046	3	1
LARGE_INTESTINE	CD532 →	+0.496	+2.652	.013	.045	3	1
LARGE_INTESTINE	123138 →	+0.296	+2.649	.047	.046	2	1
LARGE_INTESTINE	AZD7762 →	+0.508	+2.646	.047	.047	1	1
LARGE_INTESTINE	IAP_5620 →	+0.525	+2.649	.003	.046	1	1
LARGE_INTESTINE	CDK9_5038 →	+0.650	+2.906	.017	.033	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

AZD5153 by ZNF449 expression — LARGE_INTESTINE

Explore this box plot interactively →