ZNF446

Across TCGA pan-cancer cohorts, ZNF446 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated ZNF446 data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZNF446 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF446 expression acts as an unfavorable survival marker, although some lineages such as STAD show a favorable association.

UCEC and STAD are the cancer types where ZNF446 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
STAD	DFS	Median	All	1.000	0.391	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

ZNF446–UCEC (OS)

Open the UCEC breakdown →