ZNF446

Across TCGA pan-cancer cohorts, ZNF446 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF446 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ZNF446 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF446 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC, HNSC, and UCEC are the cancer types where ZNF446 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.923	0.425	.002	43	view →
HNSC	OS	Quartile	III,IV	0.595	0.867	.008	15	view →
UCEC	DFS	Quartile	III,IV	0.403	1.000	.040	4	view →
LUAD	DFS	Quartile	II,III,IV	0.825	1.000	.024	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZNF446–CCRCC (DFS)

Open the CCRCC breakdown →